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Filtered Search Results
Medchemexpress LLC Maleimido-tri(ethylene glycol)-propionic acid | 518044-40-1 | 98.0% | 301.29 | C13H19NO7 | 100 MG
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Maleimido-tri(ethylene glycol)-propionic acid is a PEG-based maleimide linker used as a cleavable linker in antibody-drug conjugate (ADC) synthesis and as a PROTAC linker. It has formula C13H19NO7, molecular weight 301.29 g·mol⁻¹, and is supplied at 98.0% purity. Recommended storage: pure form -20°C (up to 3 years) or 4°C (up to 2 years); in solution -80°C (6 months) or -20°C (1 month).
- Cleavable maleimide PEG3 linker for site-specific cysteine conjugation.
- Suitable for ADC and PROTAC synthesis.
- High purity, 98.0%.
- Molecular weight 301.29 g·mol⁻¹.
- CAS number 518044-40-1.
- Available in quantities from milligram to gram scale, including 100 mg.
- Store frozen or refrigerated according to storage guidance.
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Medchemexpress LLC Arundic acid | 185517-21-9 | MFCD08458423 | 98.0% | 186.29 | C11H22O2 | 50 MG
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Arundic acid (CAS 185517-21-9) is a small-molecule astrocyte-modulating research reagent (C11H22O2, MW 186.29) used in neuroscience studies to modulate astrocyte activation and signaling. It has been reported to delay expansion of cerebral infarcts and to inhibit synthesis of S-100β, and is provided as a high-purity compound for research and analytical applications.
- Astrocyte-modulating activity that reduces astrocyte activation.
- Evidence of delaying cerebral infarct expansion in preclinical studies.
- Inhibits S-100β synthesis and influences glutamate transporter pathways.
- Supplied as a high-purity research reagent (purity 98.0%).
- Storage recommendations available for long-term stability.
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Medchemexpress LLC 6-cyano-2-(1-cyclohexyl-1H-indol-4-yl)-5-((E)-3-ethoxyacryloyl)-N-methylbenzamide | 2226521-65-7 | 99.6% | 428.49 g/mol | C24H24N6O2 | 10 MG
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FM-381 is a potent covalent reversible inhibitor of Janus kinase 3 (JAK3) that targets the unique Cys909 residue. It demonstrates sub-nanomolar potency and strong selectivity versus other JAK family members, and is supplied as a high-purity research reagent for biochemical and cellular studies.
- Potent JAK3 inhibition (IC50 127 pM)
- High selectivity over JAK1, JAK2, and TYK2
- High purity suitable for research applications
- Stable powder storage at -20°C for long-term use
- Soluble in DMSO (8.33 mg/mL) for in vitro assays
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![Medchemexpress LLC N-(cyanomethyl)-N-methyl-2-oxo-2-[4-(7-oxo-6,7,8,9-tetrahydro-5H-benzoannulen-5-yl)phenoxy] | 2226521-65-7 | MFCD31630713 | 99.6% | 428.49 g·mol⁻1 | C24H24N6O2 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000247345.png-250.jpg)
Medchemexpress LLC N-(cyanomethyl)-N-methyl-2-oxo-2-[4-(7-oxo-6,7,8,9-tetrahydro-5H-benzoannulen-5-yl)phenoxy] | 2226521-65-7 | MFCD31630713 | 99.6% | 428.49 g·mol⁻1 | C24H24N6O2 | 50 MG
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FM-381 is a potent, covalent reversible inhibitor selective for Janus kinase 3 (JAK3). It demonstrates sub-nanomolar potency (IC50 = 127 pM) and high selectivity versus other JAK family members, making it a useful research tool for probing JAK/STAT signaling in biochemical and cellular studies. Supplied as a high-purity material for laboratory use.
- High potency for JAK3 (IC50 = 127 pM).
- Covalent reversible mode of inhibition.
- Marked selectivity versus JAK1, JAK2, and TYK2.
- Suitable for biochemical and cellular assays.
- Provided as a high-purity research chemical.
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Medchemexpress LLC FM-381 | 2226521-65-7 | 99.6% | 428.49 g·mol^-1 | C24H24N6O2 | 5 MG
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A potent covalent reversible inhibitor of Janus kinase 3 (JAK3) that targets the unique Cys909 residue. It displays subnanomolar biochemical potency and high selectivity, and is supplied as a solid for laboratory research applications.
- IC50 of 127 pM for JAK3.
- High selectivity: ~410x vs JAK1, ~2,700x vs JAK2, ~3,600x vs TYK2.
- Purity 99.58% by analysis.
- Molecular formula C24H24N6O2; molecular weight 428.49 g·mol^-1.
- Solubility 8.33 mg/mL (≈19.44 mM) in DMSO.
- Appearance: solid, light yellow to yellow.
- Storage: powder -20°C for long term; in solvent -80°C recommended.
- For research use only.
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Medchemexpress LLC L-tryptophanamide, N-((3-methyl-1H-inden-2-yl)carbonyl)-D-alanyl-N-((1S)-2-((2R)-2-methyl-2-oxiranyl)-2-oxo- | 1416709-79-9 | 98.9% | 618.72 g·mol⁻¹ | C37H38N4O5 | 5MG
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PR-924 is a selective tripeptide epoxyketone inhibitor of the immunoproteasome β5i (LMP-7) subunit, provided as an off-white to light yellow solid for biochemical and cellular research. It shows low-nanomolar activity against LMP-7 and is supplied with a stated high purity; solubility and storage recommendations support both in vitro and in vivo use.
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Medchemexpress LLC L-tryptophanamide, n-((3-methyl-1h-inden-2-yl)carbonyl)-d-alanyl | 1416709-79-9 | 98.9% | 618.72 g·mol⁻¹ | C37H38N4O5 | 10MG
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PR-924 is a selective tripeptide epoxyketone inhibitor of the immunoproteasome subunit LMP-7, reported to inhibit LMP-7 with an IC50 of 22 nM and to induce antiproliferative and proapoptotic effects in multiple myeloma cells. It covalently modifies the proteasomal N-terminal threonine active site and is supplied as an off-white to light yellow solid for research use.
- Selective LMP-7 immunoproteasome inhibitor (IC50 = 22 nM).
- Covalently modifies proteasomal N-terminal threonine active sites.
- Molecular formula C37H38N4O5; molecular weight 618.72 g·mol⁻¹.
- High purity (~98.9%).
- Recommended solvent DMSO; solubility ~50 mg/mL with ultrasonic assistance.
- Powder storage: -20°C for long term; in solution store at -80°C for extended periods.
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Medchemexpress LLC N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((2-cyanoethyl)(methyl)amino)piperidin-1-yl)-2-oxoet | 1831144-46-7 | 99.9% | 612.03 | C28H28ClF2N9O3 | 10MG
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iJak-381 is a selective JAK1/2 inhibitor for laboratory research, used to study Janus kinase-mediated cytokine signaling and inflammatory responses. It has reported activity against IL-13, IL-4, and IL-6 pathways and has been evaluated in preclinical studies for lung-restricted inhalation delivery.
- Selective JAK1/2 inhibitor for research applications.
- Blocks IL-13, IL-4, and IL-6 signaling pathways.
- Lung-restricted profile suitable for respiratory disease models.
- High purity for reproducible experimental results.
- Supplied as a 10 mg research sample.
- Molecular formula C28H28ClF2N9O3, molecular weight 612.03.
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Medchemexpress LLC NF- B1 p105 p50 Anti 50uL | 50uL
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NF- B1 p105/p50 Antibody (YA6065) is a Rabbit-derived and non-conjugated IgG monoclonal antibody targeting to NF- B1 p105/p50
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Medchemexpress LLC Goralatide acetate | 120081-14-3 | 99.1% | 50 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Goralatide is a natural tetrapeptide that functions as a physiological regulator of hematopoiesis. It has the ability to inhibit the proliferation of primitive haematopoietic cells. This product is available as a solid with a white to off-white appearance, a molecular weight of 547.56, and a formula of C22H37N5O11. It is intended for research use only and is not for human use.
- Physiological regulator of hematopoiesis.
- Inhibits primitive haematopoietic cell proliferation.
- Available as a white to off-white solid.
- High purity of 99.12%.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide | 1258292-64-6 | 98.1% | 10 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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GDC-046 (2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide) is a small-molecule, orally bioavailable TYK2 inhibitor used for preclinical kinase research, supplied as a solid for laboratory studies.
- Potent TYK2 inhibition with low-nanomolar Ki values (TYK2 4.8 nM; JAK1 0.7 nM; JAK2 0.7 nM; JAK3 0.4 nM).
- Suitable for biochemical and cellular kinase assays.
- Solid form, commonly provided in 10 mg quantities.
- High purity reported (~98.1%).
- Molecular formula C16H13Cl2N3O2 and molecular weight 350.2 g/mol.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules 79-09-4 | Propionic acid | Oakwood Chemicals74.079 | C3H6O2 | 99.000 | CCC(O)=O | 25g | 480147985
Propionic acid | Oakwood Chemicals | 79-09-474.079 | C3H6O2 | 99.000 | CCC(O)=O | 25g | 480147985
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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BIOTAGE LLC SI-PROPYLSULFONIC ACID 25G
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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NC2308078 SI-PROPYLSULFONIC ACID 25G
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PHYTOTECHNOLOGY LABS NAPHTHALENEACETIC ACID K-NAA
NC2163072 NAPHTHALENEACETIC ACID K-NAA
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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AURUM PHARMATECH INC 2BOC-AMINO 2PROPENOIC ACID 5G
NC2580810 2BOC-AMINO 2PROPENOIC ACID 5G
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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